Be aware that all this steps you have to apply only after you have configured your store. If updates, code modifications, extension installations are needed all this points should be disabled.
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Enable all Magento cache: go to System-> Cache Management Select all types and activate them.
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Merge Javascript and CSS files: go to System->
Configuration-> Developer open two tabs “Javascript Settings” and
“CSS Settings” and set Yes in both tabs.
- Enable Flat Catalog: go to System-> Configuration-> Catalog-> Frontend set Yes in Use Flat Catalog Category and Use Flat Catalog Product dropdown lists.